Investigating the macro-tribological performance and lubrication mechanism of graphene is essential for exploring its value in engineering applications. This study compared the macro-tribological behaviors of different kinds of graphenes, namely, the graphene prepared by a physical method (PG), graphene oxide (GO), reduced graphene oxide (RGO), and chemical vapor-deposited graphene (CG). Results indicate that PG shows the lowest friction coefficient and shortest lifetime whereas GO exhibits the maximum friction coefficient and longest lifetime. The tribological behaviors of CG and RGO are intermediate between those of PG and GO because the intact graphene structure contributes to a low friction coefficient. Introducing the oxygen functional groups leads to a high friction coefficient and long wear life. In addition, the dangling bonds can accelerate structural damages, resulting in a short wear life.