The nZEB standards reduce the energy demand of these buildings to a minimum, obtaining this little energy from renewable resources. Taking these aspects into consideration, a thermoelectric cooler-heat pump is proposed to achieve the comfort temperature along the whole year. The same device can provide heat in winter and it can cool down the buildings in summer just by switching the voltage supply polarity. Heat pipes are studied to work on both sides of the thermoelectric modules in order to optimize the heat transfer as these devices present really good thermal resistances and they can work in any position. However, they present pretty different thermal resistances if they work on the cold or on the hot side of the modules. A methodology to thermally characterize these heat exchangers working in both orientations is proposed and a validated computational model is developed to optimize the thermoelectric cooler-heat pump for a nZEB application. The number of thermoelectric modules, the position of the device, the ambient temperature and the air mass flow determine the operation and consequently they need to be studied in order to optimize the application. (C) 2019 Elsevier B.V. All rights reserved.