The industrial products or wastewater rich in the mixed salts (Cl-/SO42-) not only causes the environmental damage, but also induceswaste of resource. In this study, an ED stack withmonovalent selective AEMs and conventional CEMs was employed to separate the Cl- and SO42- from simulated wastewater. The effect of current density and mass fraction percentage was investigated in order to optimize the experimental conditions during ED process. It was found that at a concentration ratio between NaCl and Na2SO4 of 95/5 (wt%/wt%) and a current density of 40 mA.cm(-2), a current efficiency of 72%, an energy consumption of 1.6 kW.h.kg(-1) NaCl and a Cl-/SO42- concentration (67.5/3.5 g.L-1) were obtained. Hence, it is appropriate and effective to separate Cl- and SO42- by ED using the monovalent selective AEMs. (C) 2018 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.