Experimental investigations and numerical analyses were conducted on the thermal attributes of a building system made with locally available structural and insulation materials. The structural material, which also offers some insulation qualities, is referred to as aerated slurry-infiltrated mesh. The insulation materials used in this building are based on biomass; the alternatives considered here include ground wood, shredded straw, and cellulose. Thermal conductivity tests were performed on aerated slurries of different bulk densities, and on the biomass-based insulation materials, some of which were prepared with different bulk densities. The competitive merits of the biomass-based indigenous insulation materials were assessed. The correlations between bulk density and thermal conductivity were evaluated and rationalized based on the prevalent mechanisms of heat transfer in different materials. The effects of temperature on the thermal conductivity of different biomass-based indigenous insulation materials were investigated. For wall insulation, a cost analysis was conducted in order to select the optimum insulation level. The thermal mass of the aerated slurry-infiltrated mesh building system was found to favor its energy-efficiency when compared with a similar wood building. (C) 2018 Elsevier Ltd. All rights reserved.