A novel method has been successfully developed to synthesize the guanidine salt of 1,1,2,2-tetranitraminoethane (TNAE). By the use of IR, H-1 and C-13 NMR spectroscopy, the structure of the guanidine salt of TNAE was thoroughly characterized. In addition to the thermal stability investigated by TG-DSC, the kinetic parameters of this kind of material including activation energy and the pro-exponential factor were also calculated by Kissinger equation. The measurements of impact and friction sensitivity were carried out respectively. According to the theoretical performance calculations, the guanidine salt of TNAE exhibited the excellent detonation pressures and velocities. The solubility analysis for guanidine salt of TNAE by HPLC was performed at different temperatures, revealing the solubility increased with the increasing of temperature. And its solubility was proved to be the best in water among all the experimented solvents, ethyl acetate, dichloromethane and acetone followed up. With the great potential in practical application, the guanidine salt of TNAE is of significant value being employed as environmentally friendly gas generant, insensitive explosive and solid propellant.