Blends of poly(epsilon-caprolactone) (PCL) with pine resin, an extract from the plant Pinus caribaea-Hondurensis was prepared by melt mixing in mass ratios from 90/10 to 50/50. The thermal, crystallization, morphological, and mechanical properties of the blends were studied by differential scanning calorimetry, Fourier transform infrared spectroscopy, polarized optical microscopy, scanning electron microscopy, and tensile test. Enzymatic degradation of the blends was investigated using porcine pancreatic and Candida rugosa lipase. Antimicrobial activity of the blends was tested against four strains of bacteria; Staphylococcus aureas, Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa using the zone inhibition method. Miscibility of the blends was confirmed by the depression in the equilibrium melting temperature (T-m(0)) of PCL estimated from Hoffman-Weeks plot and the presence of extinction rings in the spherulites of blended PCL. Interactions between the two components involved the carbonyl and the C-O-C groups. The tensile strength of the blends with low pine resin content was comparable to PCL but decreased with higher pine gum content. Enzymatic degradation of the blends increased with increasing pine resin content. The blends showed antimicrobial property with all the bacteria except E. coli. The developed biomaterial shows promising candidacy in medical applications. POLYM. ENG. SCI., 59:E32-E41, 2019. (c) 2018 Society of Plastics Engineers