A series of CuO-MnOx modified catalysts were prepared, and proposed for simultaneous removal of Hg degrees and NO from flue gas. As Mn loading value was 5%, the high value of 90% Hg and 60% NOx were removed efficiently. With gradual increasing of reaction temperature, the mercury removal efficiency (Mercury RE) first increased to 92% then decreased slightly, while NOx removal efficiency (NOx RE) exhibited a trend of continuous increase. O-2 had promotional effect on the double pollutants removal, while NH3 had slightly negative effect on Hg removal. As 5% O-2 was added into system, the removal efficiency of Hg degrees and NOx rose by 30% and 47%, respectively. Unfortunately, Mercury RE decreased to 90% in the presence of 500 ppm NH3. Overall, superior Mercury RE (> 90%) and NOx RE (78%) were performed over 8%CuO-5%MnOx/AC-H at 200 degrees C. XRD results revealed calcination affected catalysts activity by playing a role in active components formation at different temperature. In XPS spectra, new formation of HgO and Hg degrees adsorption on spent catalysts revealed the possible reaction processes that the conversion of CuO and MnO2 on fresh catalyst to other species benefited HgO formation. The removal mechanism might be a combination of Langmuir-Hinshelwood and Mars-van-Krevelen mechanism.