Shape-controlled synthesis of well-defined nanostructures offers a great opportunity to promote electrocatalytic performances while reducing the mass loading of noble metals. Herein, we show how morphology can effectively affect the electrocatalytic properties of nanocrystals for alcohol electrooxidation reaction, a key barrier to the application of fuel cells. We report the synthesis of a new generation of alloyed PtSn concave nanocubes (CNCs) through a facile one-pot wet-chemical method. Owing to strong synergistic effect between Pt and Sn, modified electronic structure, as well as high surface areas, the as-obtained alloyed PtSn CNCs can display outstanding electrocatalytic performances for liquid fuel electrooxidation. Impressively, the optimized Pt4Sn1 concave nanocubes (CNCs) can achieve a factor of 5.1 enhancements in mass activity and a factor of 5.9 enhancements in specific activity towards ethylene glycol oxidation (EGOR) in comparison with commercial Pt/C catalysts. Moreover, 4.6 and 5.3-fold enhancements in mass and specific activity were also acquired for glycerol oxidation reaction (GOR) compared to those of the commercial Pt/C, holding great promise for future application in fuel cells. (C) 2018 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.