Sorption enhanced steam methane reforming (SESMR) integrated with chemical looping combustion (CLC) is one of the most capable greener technologies that allows co-generation of H-2 from natural gas together with CO2 capture. The performance of CLC mainly depends on the sustained reactivity, strength and durability of oxygen carriers (OCs). A suitable combination of active OCs with optimal inert composition is essential to meet the overall thermal demand of integrated CLC-SESMR process. In this work, the effect of inert OC supports on the performance of CLC-SESMR has been studied through thermodynamic analysis based on steady-state plant wide models developed using ASPEN plus. Ni-based OCs are considered with two different support materials, SiC/Al2O3 and MgAl2O4 at different inert compositions ranging from 0 to 70% by weight. The sensitivity analysis results revealed that H-2 purity and CO2 captured are directly proportional to the inert composition while H-2 yield is inversely proportional. The optimal inert compositions are found to be 30% and 40% by weight for the respective cases of SiC/Al2O3 and MgAl2O4. In both the cases, the overall performance of CLC-SESMR is found to be nearly same, i.e., with 97% overall methane conversion, 96% CO2 captured, 98.3% H-2 purity, 2.24 H-2 yield, and 71.4% net plant efficiency. (C) 2018 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.