Antibiotic pollutants in wastewater may cause serious damage to the environment and human health. Therefore, it is of vital importance to remove them efficiently from wastewater. In this work, adsorption of cefradine, a typical beta-lactam antibiotic, was studied in a stable metal-organic framework (PCN-222). Remarkably, it exhibits an excellent saturated adsorption capacity of 333.33 mg g(-1), which is superior to the various reported adsorbents. It is observed that the pi-pi interaction and electrostatic interaction play essential roles in the adsorption process, leading to PCN-222 as a promising adsorbent of the class of beta-lactam antibiotics from water.