In this work, we studied the DIPE (C6H14O) production as an oxygenated compound from the catalytic performance of Fe and Cu oxides supported over alumina, on the 2-propanol dehydration reaction. The impregnation acidity effect was investigated. Samples at acid, moderately acidic, and basic pH were prepared. They were tested at 250 degrees C in a pilot micro-plant at atmospheric pressure. Catalytic results concluded the Fe3O4/gamma-Al2O3 impregnated to an acid pH showed the highest selectivity toward DIPE with adequate activity. All the catalysts at basic pH showed a complete selectivity to propylene (C3H6). The yield of DIPE on the acidity reflects that is a linear function, which is valuable for a more rational design of new catalysts. The catalysts were characterized by adsorption-desorption of N-2, X-ray diffraction, high-resolution transmission electron microscopy, and energy dispersive X-ray spectroscopy. The correlation between the textural and morphological properties of our catalysts and their catalytic activity was discussed.