This experimental study reports the results of emission and vibration characteristics of compression ignition (CI) engine with variable compression ratios (VCR) using nanoparticles added to diesel fuels. Three different nanoparticles namely, titanium (IV) dioxide (TiO2), copper (II) nitrate (Cu(NO3)(2)) and cerium (III) acetate hydrate (Ce(CH3CO2)(3)center dot H2O) were used with conventional diesel fuel at the dosage of 25 ppm and 50 ppm in order to prepare the four different test fuels. The engine tests were implemented in a single cylinder diesel engine under 4 Nm and 8 Nm engine load at a constant engine speed of 1500 rpm and at compression ratios (CR) of 17:1 and 18:1. The results showed that nanoparticles addition in the diesel fuels in ppm level did not caused any complications in the physicochemical properties but a slightly increase in heating value and cetane number. In addition, the combined effect of titanium dioxides and cerium acetate hydrate nanoparticles significantly reduced pollutants emissions regardless of NOx emissions. Especially, addition of cerium acetate hydrate into the blend fuels has become a dominant factor in the reduction of the harmful exhaust emissions. Furthermore, it was revealed that sound pressure level of engine block decreased with the addition of nanoparticles into diesel fuel which is parallel to vibration results.