Nanoporous (np) Pd-x/Sn15-x (x = 1, 5, 8, 13) and Pd-5/Sn-10-CuO-y (y = 1, 2, 3, 4) electrocatalysts are synthesized via a one-step dealloying method in NaOH solution. All of the as-prepared catalysts exhibit a bicontinuous nanoporous structure. The np-Pd-5/Sn-10 catalyst exhibits the best electrocatalytic performance among the np-Pd/Sn catalysts. Due to the bifunctional effects between Sn and Pd, the catalyst with suitable Pd/Sn atomic ratio can effectively expose Pd active sites during the methanol oxidation process. The peak current density of np-Pd-5/Sn-10 catalysts is much higher than that of np-Pd catalyst. The introduction of CuO in np-Pd/Sn catalysts could significantly improve the long-term stability for methanol electro-oxidation. The peak current density of np-Pd-5/Sn-10-CuO-2 is about 2 times higher than that of np-Pd-5/Sn-10 catalyst after the stability test. (C) 2018 Elsevier Ltd. All rights reserved.