The current article presents the extension of a recently developed optimization-based approach to process synthesis for process intensification. It generates phenomena-based flowsheet options using superstructure optimization and provides a dedicated translation into equipment-based flowsheets. The considered case-study illustrates the application of the method for the analysis of ethyl tert-butyl ether production, based on the conversion of tert-butyl alcohol, under consideration of variable configurations of a rector network and a newly introduced pervaporation-based membrane-reactor block.