Tetrabutyl ammonium iodide catalyzed cross-dehydrogenative coupling reaction between -C(sp(3))-H of isochromans and N-hydroxyphathalimide has been achieved using tert-butylhydroxyperoxide as theterminal oxidant. This method offers rapid access to prevalent -aminoxyl isochroman architectures. A diverse of synthetic isochromans was tolerated with this protocol, giving the corresponding product in moderate to good yields. [GRAPHICS] .