The honeycomb porous carbon (HPC) material is prepared by one-step pyrolysis of the wheat flour, and then a series of CuxO-CeO2/HPC monolithic catalysts are constructed via the hydrothermal method. It is found that the HPC support with interconnected porous structure and high BET surface area is capable of decreasing the particle sizes of copper species and ceria by preventing the agglomeration of nanoparticles. The small-sized CeO2 particles on HPC surface facilitate the formation of a large amount of oxygen vacancies, which not only participate in oxygen activation and oxidation of carbon monoxide but also improve the redox reactivity of copper species and ceria. Thus the CuxO-CeO2/HPC catalysts exhibit good catalytic performance in the CO-PROX reaction. Here, we address the use of low-cost and efficient carbon support in the catalytic reaction.