Synthesis, Characterization and in vitro Drug Release Studies of Sonolytically Intercalated Poly(o-anisidine)/Montmorillonite Nanocomposites

Anurakshee Verma; Ufana Riaz

Macromolecular Research, Vol.27, No.2, 140-152, February, 2019

DOI10.1007/s13233-019-7037-0Verma Export Citation

Synthesis, Characterization and in vitro Drug Release Studies of Sonolytically Intercalated Poly(o-anisidine)/Montmorillonite Nanocomposites

Anurakshee Verma, and Ufana Riaz^†

Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India

E-mail:

In the present study, in situ intercalation and polymerization of o-anisidine within montmorillonite (MMT) clay was carried out via ultrasonication using different loadings of o-anisidine (12.5 wt%, 25 wt%, and 50 wt%). Infrared (IR) spectra indicated successful incorporation of poly(o-anisidine) (PAnis) in MMT. Ultraviolet (UV)-visible spectra confirmed the polaronic state of nanocomposites, while X-ray diffraction (XRD) analysis revealed intercalation of PAnis in the interlayer space of MMT. Transmission electron microscope (TEM) and optical micrographs showed nanomorphology of prepared nanocomposites. The nanocomposites were modified by loading with anti-migraine drug in different concentrations to investigate the adsorption profiles in gastric fluid (pH 1.2) and intestinal fluid (pH 7.4). The adsorption profiles followed the Langmuir isotherm. Release kinetics followed zero order model and parabolic diffusion model in gastric fluid (pH 1.2) and intestinal fluid (pH 7.4). The nanocomposites were found to show fast release behavior and hold potential to be used as an effective antidepressant drug delivery vehicle.

Keywords:nanocomposites;drug delivery system;release kinetics;drug interaction;clay;conducting polymer

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[1] Ashraf SM, Ahmad SR, Riaz U, J. Appl. Polym. Sci., 93(1), 82 (2004)

[2] Ashraf SM, Ahmad S, Riaz U, Dua R, J. Macromol. Sci.-Pure Appl. Chem., 42, 521 (2005)

[3] Riaz U, Ahmad S, Ashraf SM, J. Nanopart. Res., 10, 1209 (2008)

[4] Riaz U, Jahan R, Ahmad S, Ashraf SM, J. Appl. Polym. Sci., 108(4), 2604 (2008)

[5] Ashraf SM, hmad S, Riaz U, Des. Monomers Polym., 11, 201 (2008)

[6] Geetha S, Rao CRK, Vijayan M, Trivedi DC, Anal. Chim. Acta, 568, 119 (2006)

[7] Liu X, Gilmore JK, Moulton SE, Wallace GG, J. Neural Eng., 6, 1 (2009)

[8] Olszowy P, Szultka M, Ligor T, Mowaczyk J, Buszewsk B, J. Chromatogr. B, 878, 2226 (2010)

[9] Seyfoddin A, Chan A, Chen WT, Rupentha ID, Waterhouse GI, Svirskis D, Eur. J. Pharm. Biopharm., 94, 419 (2015)

[10] Alshammary B, Casillas N, Swingler J, Cook RB, Leon CPD, Walsh FC, J. Solid State Chem., 20, 3375 (2016)

[11] Svirskis D, Sejdic JT, Rodgers A, Garg S, J. Control. Release, 146, 6 (2010)

[12] Esrafilzadeh D, Moulton SE, Razal JM, Stewart EM, Wallace GG, Fiber Society Spring Technical Conference, 244, 2013.

[13] Joshi GV, Kevadiya BD, Patel HA, Bajaj HC, Jasra RV, Int. J. Pharm., 374, 53 (2009)

[14] Riaz U, Ashraf SM, Mini Rev. Med. Chem., 13, 522 (2013)

[15] Chen Y, Zhou A, Liu B, Liang J, Appl. Clay Sci., 49, 108 (2010)

[16] Iliescu RI, Andronescu E, Voicu G, Ficai A, Covaliu CI, Appl. Clay Sci., 52, 62 (2011)

[17] Dong Y, Feng SS, Biomaterials, 26, 6068 (2005)

[18] Zheng JP, Luan L, Wang HY, Xi LF, Yao KD, Appl. Clay Sci., 36, 297 (2007)

[19] Lin FH, Lee YH, Jian CH, Wong JM, Shieh MJ, Wang CY, Biomaterials, 23, 1981 (2002)

[20] Fejer I, Kata M, Eros I, Berkesi O, Dekani I, Colloid Polym. Sci., 279, 1177 (2001)

[21] Nunes CD, Vaz PD, Fernandes AC, Ferreira P, Romao CC, Calhorda MJ, Eur. J. Pharm. Biopharm., 66, 357 (2007)

[22] Lagasse RR, Thompson KR, Polymer, 43(3), 803 (2002)

[23] Kim DW, Blumstein A, Tripathy SK, Chem. Mater., 13, 1916 (2001)

[24] Lim ST, Choi HJ, Jhon MS, J. Ind. Eng. Chem., 9(1), 51 (2003)

[25] Riaz U, Ashraf SM, J. Phys. Chem. C, 116, 12366 (2012)

[26] Riaz U, Ashraf SM, Verma A, Recent Pat. Nanotechnol., 10, 66 (2016)

[27] Anirudhan TS, Tharun AR, Rejeena SR, Ind. Eng. Chem. Res., 50(4), 1866 (2011)

[28] Riaz U, Ashraf SM, Chem. Eng. J., 174(2-3), 546 (2011)

[29] Kaur M, Datta M, Adsorp. Sci. Technol., 32, 365 (2014)

[30] Chandrasekaran AR, Jia CY, Theng CS, Muniandy T, Muralidharan S, Dhanaraj SA, J. Appl. Pharm. Sci., 1, 214 (2011)

[31] Singhvi G, Singh M, Int. J. Pharm. Res., 2, 77 (2011)

[32] Yang JH, Han YS, Park M, Park T, Hwang SJ, Choy JH, Chem. Mater., 19, 2679 (2007)

[33] Sehati S, Entezari MH, Ultrason. Sonochem., 32, 348 (2016)

[34] Gedanken A, Ultrason. Sonochem., 14, 418 (2007)

[35] Agarwal S, Ganguli JN, RSC Adv., 4, 11893 (2014)

[36] Verma A, Riaz U, Int. J. Polym. Mater. Polym. Biomater., 67, 221 (2018)

[37] Verma A, Riaz U, J. Mol. Liq., 261, 1 (2018)