The continuous flow inside cyclone separator is usually simulated by solving the Reynolds averaged Navier-Stokes equations in Eulerian reference frame whereas the dispersed phase is modeled using Lagrangian approach. Although these methods have had a remarkable success, more advanced ideas are needed to model particulate phase in cyclones, especially the non-spherical shaped particles. Numerical simulation is verified with experimental results for the gas-solid flow in a cyclone separator. Reynolds Averaged Navier-Stokes equations (RANS) employing the RNG-based k-epsilon turbulence model are used to simulate the gas phase. 3-D particle tracking procedure is used for the solid phase. Three different equations for the drag coefficient are utilized in the numerical modeling to acquire more understanding of the behavior of non-spherical particles in cyclones. Computations resulted in the difference of pressure between the inlet and exit of the cyclone, and results are compared with experimental data. Experiments included measuring the separation efficiency of different shapes and sizes of particles. The results indicate that the CFD simulation can effectively reveal the pressure drop behavior as well as separation efficiency of gas-non-spherical particle flow in cyclone.