The present work evaluates the electrocatalytic performance of hydrothermally derived tin oxide/ reduced graphene nanocomposites (SnO2/RGO) toward riboflavin (VB2) detection. The physicochemical properties of the samples were studied by using various analytical techniques. The cyclic voltammetric profiles reveal the quasi-reversible catalytic behavior of electrodes and the linear plot evidence the interfacial electron transfer kinetics dominates the diffusion of VB2 on SnO2/RGO. The Anodic stripping voltammetry was used to optimize the pertinent time (80 sec) and potential (-1.3 V) to study their influence on anodic peak current responses. The square wave pulse voltammetry responses exhibit a significant linearity in the range of 0.1-150 mu mol.L-1 and lower detection limit of 34 nmol.L-1 without any interference effect. The sensitivity perceived above 98.5% in real sample analyses assures that the prepared synergetic electrode can be employed for VB2 quantification in pharmaceutical compounds and energy drinks in practice with adequate outcomes. (C) 2018 The Electrochemical Society.