Ultra-sensitive H2S sensors operated at room temperature were fabricated using Ag-In2O3 nanorod composites synthesized using sol-hydrothermal method followed by NaBH4 reduction process. TEM proved that the In2O3 was nanorod structures of110nm in length and35nm in diameter. Ag nanoparticles with diameters from 10 to 15nm homogeneously decorated on the surfaces of the In2O3 naonorods. XRD and XPS analysis proved that the Ag elements existed as zero-valent metallic silver on the surface of the In2O3 nanorods. Ag nanoparticles could enhance the formation of chemisorbed oxygen species and interactions between H2S molecules and oxygen species due to spillover effect, and the electron transfer between Ag and In2O3 nanorods also enhanced the sensing properties. Therefore, the H2S sensors based on the Ag-In2O3 nanorod composites showed significantly improved sensing performance than those based on the pure In2O3 nanorods. The optimized content of Ag nanoparticles is 13.6wt%. Operated at room temperature, the H2S sensors made of 13.6wt% Ag-In2O3 nanorod composites exhibited an ultra-high response of 93719 to 20ppm H2S and a superior detection limit of 0.005ppm. The sensor also showed good reversibility, good selectivity, excellent reproducibility and stability for detection of H2S gas.