Several classes of antihistamine drugs are widely distributed over the world's medication although their intensive side effects are in the high dosages. In the present manuscript, we report a simple, cost-effective and sensitive voltammetric determination of the meclizine antihistamine drug using unmodified/bare graphite screen-printed electrodes (GSPE) within physiological micellar medium of sodium dodecyl sulphate (SDS). The GSPE show an electrochemical oxidation peak of meclizine at +1.0 V vs. Ag/AgCl. It was found that, the voltammetric peak height of meclizine was markedly increased almost three-times in B. R. Buffer of pH 7.0 containing 0.067 g/L of SDS. This significant enhancement is due to their uniform assemblage of SDS molecules on the graphite surface which promotes the electrostatic interactions of the meclizine drug with GSPE. Under the optimum experimental conditions, the determination of meclizine were explored in a wide concentration range of 33 x 10(-8)-29.13 x 10(-6) mol/L with a nanomolar detection limit (LOD) of 80 x 10(-9) mol/L. Furthermore, the GSPE was utilized for determination of meclizine within pharmaceutical tablets and human fluids with satisfactory accuracy and precision.