An accelerating rate calorimeter (ARC) is used to measure the thermal stability of de-intercalated Li1+xMn2-xO4 in LiPF6 EC:DEC (33:67) electrolyte. Self-heating is detected well after the 80 degrees C onset of self-heating measured for lithium intercalated mesocarbon microbead (MCMB) electrodes in LiPF6 EC:DEC (33:67) electrolyte. As a result, the initial self-heating measured in a practical carbon/Li1+xMn2-xO4 lithium-ion cell is caused by reactions at the anode. In previous work, we have proposed a model for the reactions that cause self-heating in MCMB electrodes in electrolyte. By assuming that a cell self-heats only because reactions occur at the anode, the model can be used to predict the power generated by the amount of MCMB in practical cells with an inert cathode. The calculated chemically generated power can be combined with power loss measurements, due to the transfer of heat to the environment, to predict the short-circuit behaviour and the oven exposure behaviour for a cell containing an MCMB anode and an inert cathode. The results agree qualitatively with short-circuit and oven exposure results measured on NEC Moli energy 18650 cells containing an Li1+xMn2-xO4 cathode.