The solubilities of three antofloxacin salts (antofloxacin hydrochloride, antofloxacin sulfate, and antofloxacin succinate) in six organic solvents, including methanol, ethanol, n-propanol, n-butanol, acetonitrile, and N,N-dimethylformamide (DMF), were determined experimentally over a temperature range from 273.15 to 318.15 K under 101.3 kPa. Within the temperature range studied, the solubility of these three compounds in the solvents increased with a rise of temperature. The solubility values of antofloxacin hydrochloride in these six solvents obey the following order: (methanol, DMF) > n-butanol > ethanol > n-propanol > acetonitrile. For the systems of antofloxacin sulfate + solvents, it ranked as DMF > methanol > ethanol > acetonitrile > n-propanol > n-butanol. While for ethanol > acetonitrile. The solubility data obtained for these three compounds in the studied solvents were correlated by using the modified Apelblat and lambda h equations. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) were 3.3 x 10(-5) and 4.06%, respectively. Generally, the RAD values acquired with the modified Apelblat equation were smaller than lambda h equation for a certain solvent. The two thermodynamic models were all acceptable for the systems of these three compounds in these solvents. The obtained solubility values would be very helpful for drug application of antofloxacin hydrochloride, antofloxacin sulfate, and antofloxacin succinate.