Experimental solubility data of L-fucose in methanol + water, ethanol + water, 2-propanol + water, and acetone + water systems were measured at temperatures ranging from 288.15 to 308.15 K under atmosphere pressure (P = 0.1 MPa), using the gravimetric method. The experimental results indicate that the solubility of L-fucose increases with increasing temperature and water content, as well as decreasing with the composition of organic solvents used in this work. According to the data measured in this experiment, methanol is less effective than ethanol, 2-propanol, and acetone in the antisolvent crystallization process of L-fucose. By means of our research, the solubility of L-fucose in the pure solvents was affected by polarity and hydrogen bond. The modified Apelblat model, CNIBS/R-K model, and Apelblat-Jouyban-Acree model were used to correlate the solubility data, and all three of the thermodynamic models were found to agree well with the measured experimental solubility data.