Isopropanol is regarded as one of the most promising anodic electrooxidation candidates for direct alcohol fuel cells. However, developing the efficacious electrocatalysts remains the critical issue in the propelling of isopropanol electrooxidation. In this study, a good electrocatalyst combined with the benefits of a novel N-doping carbon support (CN support) and Pd-based alloy nanoparticles (Pd3Fe anchoring on CN support, Pd3Fe/CN), was successfully prepared and estimated. Electrochemical results indicate that the as-obtained Pd3Fe/CN electrocatalyst possesses larger electrochemical active surface area, higher activity, better anti-CO poisoning and superior stability compared to Pd/C towards isopropanol electrooxidation. This work would propose a good electrocatalyst for the development of isopropanol electrooxidation. (C) 2018 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.