Mesoporous silica (MS) and a series of completely new MS incorporated by Ce/Zr (CZ-MS) supports were synthesized by hydrothermal synthesis method. 30 wt % Ni were impregnated in the supports. N-2 adsorption-desorption, FTIR, XRD, TEM, H-2-TPR, CO-TPD and XPS were used to characterize the catalysts. And results showed Ce and Zr were successfully incorporated into the structure of MS. The CZ-MS supports provided an appropriate interaction with Ni active metal to promote the dispersibility of Ni and restrain catalysts from sintering. Compared with Ni/MS, Ni/1CZ-1MS showed better ability of antisintering and kept high catalytic activity after calcination at 700 degrees C for 3 h. The series of Ni/CZ-MS exhibited more excellent catalytic activity than Ni/MS at 200-450 degrees C. Ni/1CZ-1MS exhibited the best catalytic property at low temperature of 200 degrees C. CO conversion and CH4 selectivity reached 91.12% and 84.40%, respectively. Ni/1CZ-1MS also showed excellent catalytic stability in harsh reaction conditions.