In order to investigate the relationship between outdoor air pollution and sick building syndrome (SBS)symptoms, the CCHH (China, Children, Home, Health) group in Shanghai conducted a cross-sectional survey on the current incidence of SBS symptoms among residents in five districts of Shanghai during April 2011-April 2012. It also collected the related outdoor air pollutants data from Shanghai environmental monitoring center (SEMC), including nitrogen dioxide (NO2), sulfur dioxide (SO2) and particles with aerodynamic diameter less than 10 pm (PM10). The logistic regression models were used in this paper to study the associations between air pollutants and SBS symptoms. Results were found that the daily mean concentrations of NO2 and SO2 met standard requirement, but that of PM10 exceeded the limit values of the standard in China during this survey. The significant differences were found between the pollutants concentration in urban and suburban area. In addition, the incidences of three categories of SBS symptoms among residents were 79.1% for general symptoms (GS), 65.2% for mucous membrane symptoms (MS) and 35.7% for skin symptoms (SS), respectively. Multiple logistic regression analysis by two case studies illustrated that three outdoor air pollutants, both their concentration quartiles and equal increment, were all associated to and taken as the risk factors for SBS symptoms, for GS ORNO2 = 1.62 (1.18-2.22), MS OR NO2 = 1.58 (1.21-2.06) and SS OR PM10 = 1.21 (1.09-1.35). Furthermore, the new pollutants expressed as the mixtures of their combination were also significantly associated with part of the SBS symptoms. The synthetic air quality indexes of all surveyed residents were calculated as Ill-level, which represented mild pollution. Therefore, it would be an effective way to decrease the incidence of SBS symptoms in residence to reduce the outdoor air pollution and control the penetration from outdoor to indoor environment. (C) 2018 Elsevier B.V. All rights reserved.