Oxidation of iso-propylbenzene (IPB) has been studied over the temperature range from 700 to 1100 K in a jet stirred reactor (JSR) at low-temperature, which is operated at atmospheric pressure from fuel-lean to fuel-rich condition with residence time from 1.06 to 1.67 s. Reactants and 25 species were identified and quantified by online GC-MS and GC analysis. A new model involving 306 species and 1985 reactions for low-temperature oxidation of IPB was developed, whose predictions were in good agreement with the measured profiles of mole fraction. Sensitivity analysis indicates that the primary H atom abstraction from the side iso-propyl chain has significant promoting effect and H-abstraction from the tertiary site of side isopropyl tends to play an inhibiting effect under fuel-lean and fuel-rich cases. The predominant consumption pathway of IPB proceeds through primary benzylic H atom abstraction to form iso-phenylpropyl radicals for both fuel-lean and fuel-rich cases. However, compared to the fuel-rich condition, 1-iso-phenylpropyl is favorable kinetically under the fuel-lean condition. Both simulated and experimental results show that styrene and phenol are most abundant and stable monocyclic aromatic intermediates for IPB oxidation at low-temperature. These experimental and modeling works will expand the research area of low-temperature oxidation of IPB and provide insights on understanding the combustion mechanism of IPB.