The microstructure of amorphous polymer blends has been extensively studied in the past, but now there is a growing interest for polymer blends where one or more of the components can crystallize. In this study we investigate such blends, namely miscible polycarbonate (PC)/acrylic blends. Using small angle X-ray scattering (SAXS) measurements, combined with atomic force microscopy (AFM), electron microscopy (SEM), and optical microscopy, we demonstrate that the amorphous acrylic component mostly segregates inside the spherulites between the lamellar bundles (interfibrillar segregation). Varying the PC molecular weight or the mobility of the amorphous component (by changing its molecular weight and T-g) does not change the mode of segregation. So far qualitative predictions of the mode of segregation in semicrystalline polymer blends have been proposed using the delta parameter (the ratio between the diffusion coefficient D of the amorphous component in the blend and the linear crystallization rate G), introduced by Keith and Padden. Our results suggest that other parameters have to be considered to fully understand the segregation process.