A simulation-based optimization for water electrolysis is performed to identify preferable scenarios with respect to economic as well as ecological aspects. As the electrolyzer interacts with the wholesale electricity market and with the production of bulk chemicals implying each specific dynamic characteristics, various and partly counteracting relevant impulses result in a multi-objective optimization approach. In order to demonstrate the capability of alkaline electrolytic systems to meet these dynamic demands, a 20-kW lab-scale electrolyzer and a 2-MW large-scale electrolyzer are commissioned and tested.