In this paper, zwitterionic graphene oxide (ZGO) was prepared with two silanes. It was evident that the silane molecules were grafted on GO surfaces by covalent bondings. zeta potential of ZGO varied from -29.0 mV to +28.5 mV when the pH of the aqueous solution was changed from 12 to 2. As a result, the ZGO can be dispersed in both anionic and cationic waterborne polymer matrix. Besides, ZGO can be used as two-dimensional surfactant in a wider range of pH values than GO. The multi-applications of ZGO were enabled by the unique pH-responsive charge-conversion properties and pH-insusceptible amphiphilicity. (C) 2018 Elsevier B.V. All rights reserved.