This study investigates the extent of drug (active) migration in granules made via high shear wet granulation subject to factors such as the viscosity of the binder solution, particle size of the excipient and granule porosity. Due to the complexity of a qualitative comparison between granules having different sizes, shape and porosities, a quantification technique that is independent of these differences was developed. The radial distribution function (RDF), developed as part of this effort, quantifies the spatial distribution of the active ingredient in granules produced under different processing conditions. A two component system with potassium chloride (KCl) as the water-soluble model active and microcrystalline cellulose (MCC) was studied at 20% (w/w) active load. In order to eliminate any non-homogeneity due to segregation and difference in wettability of the two compounds, the soluble active ingredient was dissolved in the granulating vehicle and then sprayed on the powder bed to carry out granulation. The extent of drug migration and structure of the dry granules was analysed using X-ray microtomography (mu-CT). The extent of capillary migration in the resulting granules was analysed by the dividing the mu-CT images into conical sections and quantifying the distribution of the active across these conical cross-sections. Statistical analysis was performed to quantify the extent of aforementioned variables on the extent of migration. Thus, a comprehensive investigation into the causes of drug migration was carried out in this study to ascertain which factors or combination of factors have the most prominent effect on the extent of drug migration. (C) 2018 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.