In the present work, degradation of Atrazine (ATZ) has been investigated using novel treatment techniques based on hydrodynamic cavitation for the first time with intensification studies involving combination with chemical oxidants. Effect of operating parameters such as pressure and initial pH on the extent of degradation has been initially investigated. Under the optimized set of operating parameters, the effect of addition of hydrogen peroxide (ratio of ATZ: H2O2 varied over 1:05 to 1:10), Fe+ activated sodium persulfate (SPS) (ratio of ATZ:SPS:Fe+ varied over 1:1:1 to 1:2:15), and solids (ZnO, TiO2, CuO) as well as combination with ultraviolet irradiation (UV) on the atrazine degradation has been investigated. Comparison of kinetic rate constants, extent of ATZ removal and reduction in COD established that combination approaches resulted in higher efficacy as compared to individual approaches and in most cases synergism was also observed. Combinations of HC+H2O2+SPS, HC + Fe++SPS and HC + UV + SPS resulted in complete degradation for all approaches and extent of COD reduction as 87%, 78% and 83% respectively. The combination of HC+ H2O2 +SPS was established as the best treatment approach yielding complete degradation and maximum COD reduction of 87%. Overall, the work has demonstrated that hybrid treatment approach based on cavitation can be effectively used for degradation of ATZ.