This study investigates a parameter optimization approach to maximize the specific growth rate of the Chlorella vulgaris microalgae species, its biomass productivity, and CO2 capture rate. For this purpose, the Box-Behnken experimental design technique is applied with temperature, nitrogen to phosphorus ratio, and light-dark cycle per day, as the growth controlling parameters. For each response, a quadratic model is developed separately describing the algal specific growth rate, biomass productivity, and CO2 capture rate, respectively. The maximum specific growth rate of 0.84 d(-1) is obtained at 25 degrees C, with a nitrogen to phosphorus ratio of 3.4:1, and light-dark cycles of 24/0h. Maximum biomass productivity of 147.3mgL(-1) d(-1) is found at 30 degrees C, with a nitrogen to phosphorus ratio of 3:1, and light-dark cycles of 12/12h. In addition, the maximum CO2 capture rate of 159.5mgL(-1) d(-1) is also obtained at 30 degrees C, with a nitrogen to phosphorus ratio of 4:1, and light-dark cycles of 23/1h. Finally, a multi-response optimization method is applied to maximize the specific growth rate, biomass productivity, and CO2 capture rate, simultaneously. The optimal set of 30 degrees C, a nitrogen to phosphorus ratio 3:1, and light-dark cycles 16/8h, provide the maximum specific growth rate of 0.66 per day, biomass productivity of 147.6mgL(-1) d(-1), and CO2 capture rate of 141.7mgL(-1) d(-1).