Membrane bioreactors (MBRs) have attracted attention in water reclamation as a result of the recent technical advances and cost reduction in membranes. However, the increasing occurrence of micropollutants in waste-waters has posed new challenges. Therefore, we reviewed the current state of research to identify the outstanding needs in this field. In general, the fate of micropollutants in MBRs relates to sorption, biodegradation and membrane separation processes. Hydrophobic, nonionized micropollutants are favorable in sorption, and the biological degradation shows higher efficiency at relatively long SRTs (30-40 days) and HRTs (20-30 h), as a result of co-metabolism, metabolism and/or ion trapping. Although the membrane rejection rates for micropollutants are generally minor, final water quality can be improved via combination with other technologies. This review highlights the challenges and perspectives that should be addressed to facilitate the extended use of MBRs for the removal of micropollutants in water reclamation.