Electromagnetic radiation pollution has become a serious threat to human health. Wearable materials with high electromagnetic interference (EMI) shielding are highly desirable to protect people far from electromagnetic radiation. In this study, we prepared flexible and wearable materials with ultrahigh EMI shielding via a facile wet electroless deposition of Ag on surface of cotton fibers (Ag@CFs) in non-woven fabrics. High conductivity of similar to 3333 S/m and excellent EMI shielding effectiveness (SE) of similar to 71 dB were achieved by only costing the wet deposition time of 10 s with 1.61 vol% Ag coating layers, which was far more than the requirement for common commercial EMI SE of 30 dB. The EMI SE of the materials could reach similar to 111 dB when the Ag plating time was 3 min. The ultrahigh EMI shielding performance was ascribed to cell-like configuration, which is the abundant interfaces and porous structure in the Ag@CFs non-woven fabrics, and the voids in Ag layers. The electro-magnetic radiation, which was reflected at the interfaces and then absorbed in the composites, was hard to escape from the cell-like configurations. Moreover, the prepared Ag@CFs films could also maintain high EMI SE by suffering dozens of washing times or one thousands of bending times. For example, there were only reduction of a few dB in the EMI SE for the non-woven fabrics with the coating time of 3 min after washing 20 times or bending 1000 times. Therefore, this work gave a new strategy for fabricating wearable materials with high-performance EMI shielding.