Nickel ferrite magnetic nanoparticles (NiFe2O4 MNPs) were prepared via the autocombustion assisted solgel method. The efficient catalyst was investigated by FT-IR, XRD, ICP, SEM, and TEM techniques. A one-pot, three-component reaction is reported for the synthesis of substituted 4 H-chromenes in the presence of NiFe2O4 MNPs as a reusable catalyst in a green solvent at 40 degrees C under clean, efficient, and mild conditions. Furthermore, selected products were characterized by FT-IR, H-1 NMR, and C-13 NMR. The single-crystal X-ray analysis of product 4u was also conclusively confirmed. Easy workup procedure, high purity of products via simple recrystallization, and environmentally benign conditions are the outstanding benefits of this method.