In this study, encapsulation processes of cetyltrimethylammonium bromide (CTAB) or sodium dodecyl sulfate (SDS) monomers into the cavity of beta-cyclodextrin (beta-CD) were applied to synthesize mono- and bis (indolyl)methylmalonomtrile derivatives by a one-pot three-component reaction of an aldehyde, malononitrile, and indole in an aqueous solution. These two inclusion complexes proved to be superior to CTAB or SDS individually, as cationic or anionic surfactants, respectively, for accessing high yields of pure products within shorter reaction times. In addition, simple isolation of products and mild reaction conditions are the other advantages of this green procedure.