The main aim of the study was to examine the Sinorhizobium meliloti1021 exopolysaccharide (EPS) flocculation efficiency relative to mineral oxide suspensions and verify if EPS can be used in the wastewater treatment procedure. The paper compares the EPS adsorption influence on the stability of various mineral oxide suspensions (chromium(III) oxide, silica, zirconia). Moreover, it indicates the solid whose aqueous suspension is the most destabilized in the EPS presence. The selected adsorbents have different surface properties. They are characterized by different pH(pzc) (zero surface charge) and pH(iep) (isoelectric) points. The highest adsorption amount was observed on the chromium(III) oxide surface. It resulted in the greatest changes in the particle zeta potential and surface charge density. The exopolysaccharide addition affects the stability of all mineral oxide suspensions. The most significant changes were observed for chromium(III) oxide and zirconia at pH 9. Under these conditions there is a bridging flocculation in the system, so the S. meliloti exopolysaccharide can be regarded as a potential flocculant related to these solids. In turn, the silica suspension stability changes insignificantly in the EPS presence.