This study was devoted to an exergetically investigation and optimization of the operating conditions of an easy-to-scale-up continuous reactor applied for solketalacetin synthesis as a green fuel additive from glycerol-derived monoacetin in the presence of Purolite PD 206 catalyst. The process consisted of two steps, i.e., monoacetin synthesis by glycerol esterification with acetic acid followed by solketalacetin synthesis through reaction of the produced monoacetin with acetone. The main goal of this research was to assess the effects of reaction temperature (20-80 degrees C), acetone to monoacetin molar ratio (1-5), catalyst loading (0.5-2.5 g), feed flow rate (0.2-1 mL/min), and pressure (0-120 bar) on the exergetic performance parameters of the second stage of the process. Response surface methodology (RSM) was also used to optimize the operating conditions of the reactor by maximizing functional exergetic efficiency (FEE) and minimizing normalized exergy destruction (NED), simultaneously. Overall, feed flow rate had the highest impact on the exergetic performance parameters of the reactor while these indicators were not significantly influenced by pressure. RSM successfully modeled both exergetic parameters with an R-2 higher than 0.99. Reaction temperature of 30.8 degrees C, acetone to monoacetin molar ratio of 2.7, catalyst loading of 1.6 g, feed flow rate of 1.0 mL/min, and pressure of 14.5 bar yielding FEE of 2039% and NED of 0.90 were determined as the best operating conditions of the reactor. According to the results archived, process yield alone could not stand as the primary objective for making decisions on the optimal operating conditions of the chemical reactors, further highlighting the significance of taking energetic parameters into account in parallel. (C) 2018 Elsevier Ltd. All rights reserved.