The IEC 61511 standard requires a verification calculation that a proposed design for a safety instrumented function (SIF) achieves the desired safety integrity level (SIL). The evaluation of the SIL of a new or existing safety instrumented system requires detailed calculations based on the failure rates of the device and the planned maintenance/testing cycle for the system. The failure rates of the devices are often taken from standard failure rate tabulations of equipment. The maintenance and testing plans are developed based on plant experience. All of the data used in the SIL calculations are uncertain. This article develops a general method for uncertainty analysis of the SIL calculations. The general method is based on the application of probability theory-variance contribution analysis-to the equations presented in ISA TR 84.00.02-2115. An example is worked to demonstrate the methodology. (c) 2017 American Institute of Chemical Engineers Process Saf Prog 37: 153-160, 2018