Herein, we report a novel, disposable electrochemical sensor for the detection of nitrite ions in food samples based on the sonochemical synthesized orthorhombic CaFe2O4 (CFO) clusters modified screen printed electrode. As synthesized CFO clusters were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformer infrared spectroscopy (FT-IR), Thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and amperometry (i-t). Under optimal condition, the CFO modified electrode displayed a rapid current response to nitrite, a linear response range from 0.016 to 1921 mu M associated with a low detection limit 6.6 nM. The suggested sensor also showed the excellent sensitivity of 3.712 mu A mu M-1 cm(-2). Furthermore, a good reproducibility, long-term stability and excellent selectivity were also attained on the proposed sensor. In addition, the practical applicability of the sensor was investigated via meat samples, tap water and drinking water, and showed desirable recovery rate, representing its possibilities for practical application. (C) 2018 Elsevier Inc. All rights reserved.