BaTNR (barium trinitroresorcinate) particles were first synthesized through a segmented flow synthesis method. The optimal synthesis conditions of barium trinitroresorcinate (BaTNR) were obtained by orthogonal experimental design using segmented flow technology. The optimal synthesis conditions are composed of barium nitrate solution with a pH value of 5.5 and molar concentration of 0.20 mo1.1.L-1, magnesium styphnate solution with a pH value of 4.5 and molar concentration of 0.15 mol.L-1, and reaction temperature of 65 degrees C. The optimized batch conditions were compared with segmented flow arrangements through a reproducibility experiment, which indicates that BaTNR synthesized by segmented flow is superior to a conventional technique in terms of crystal morphology, uniformity and yield. In addition, the possibility of continuous and safe synthesis of BaTNR using micro-segmented flow technology is introduced.