Vapor-liquid equilibrium (VLE) property measurements for 2,3,3,3-tetrafluoroprop-1-ene (HFO-1234yf) + butane (HC-600) were carried out. The range of temperature is from 283.15 to 323.15 K, and the corresponding range of pressure is from 0.148 to 1.30 MPa. The experimental uncertainties in pressure, temperature, and mole fraction are estimated within 3.5 kPa, 5 mK, and 0.003, respectively. Peng-Robinson (PR) equation of state coupling with Wong-Sandler (WS) mixing rule and van der Waals (vdW) mixing rule were used to correlate the experimental VLE data of HFO-1234yf/HC-600. Both of the two models reproduce the VLE property of HFO-1234yf/HC-600 with high accuracy, and PR-WS-NRTL model gave slightly more accurate VLE calculations. Azeotropic behavior was found at high mole fraction of HFO-1234yf.