Effects of ambient temperature, pressure and relative velocity between droplet and airflow on evaporation characteristics of multi-component droplet were investigated numerically. A recently proposed multi-component model was adopted in the present study by considering the pressure effects. The result shows that, present model predicts satisfactory results when compares with experimental data. Increasing ambient temperature especially promotes evaporation of low volatile components in ABE20. Ambient pressure influences ABE-diesel blends droplet evaporation differently under various ambient temperatures. For low ambient temperature environment, droplet evaporation rate decreases with ambient pressure increasing, especially for low diffusion coefficient components. However, evaporation characteristic shows an opposite tend under high ambient temperature environment, where evaporation rate increases with ambient pressure increasing. Additionally, increasing ambient pressure promotes maximum evaporation rate of high diffusion coefficient components. With temperature increasing, this promotion extends to low diffusion coefficient components. Finally, increase relative velocity between liquid and gas phase substantially enhances evaporation of high diffusion coefficient components in the mixture.