Air dehumidification is widely applied in the civilian and industrial use, however, conventional vapor compression air-conditioning system consumes substantial power. Using renewable energy in the air handling process has potential to further reduce the power consumption, meanwhile ease the carbon emission. This paper proposes a novel liquid desiccant system integrated with a concentrated photovoltaic/thermal collector for deep dehumidification. The generated electric power drives a vapor compression chiller for cooling the desiccant solution for a two-stage dehumidification, and the released heat from the collector is used for the desiccant regeneration. Simulation studies indicated the proposed system has a superior power saving ability of 55.65% comparing with the conventional one, besides the equivalent power generation efficiency reaches 8.7% in the base design condition. A comparative driven force analysis showed the two-stage dehumidification has a better match of driven force compared with the single-stage liquid desiccant dehumidification, thus leading to a reduced irreversible loss of 65.43%. Sensitivity analysis indicated that the dehumidification temperature has a decisive effect on the system performance. The exergy efficiency has a maximum value of 13% as the dehumidification temperature is 22.3 degrees C. The economic studies showed that the investment on the concentrated photovoltaic/thermal collector account for the largest share of the total initial investment, and has a significant effect on the payback period. The payback period would be reduced further if the benefit of the clean development mechanism (CDM) is considered.