An experimental study on electro-spraying and catalytic combustion of ethanol at meso-scale is carried out. The electro-spraying process of ethanol is visualized and four typical spraying modes are identified. Based on droplet size measurements by a Phase Doppler Anemometer, the spraying at the cone jet or multi-jet mode is suitable for meso-scale combustion. Two meso-combustors without and with the platinum catalyst, denoted as combustor A and combustor B, respectively, are designed to conduct the comparative experiments. The flame temperature at the cone-jet mode is higher than those at other modes when equivalence ratio phi = 1.0, and for the combustor with catalyst, fuel-lean conditions are favorable for stable combustion. It is also found that the carbon monoxide mole fraction in the exhaust decreases by at least 25% due to the catalytic effect. At the cone-jet electro-spraying mode, the combustion efficiencies of ethanol reach the highest value for both combustor A and combustor B due to smaller droplet size and more uniform droplet size distribution. Under the same conditions, combustion efficiency of ethanol can be improved by 4.5% for combustor B, which proves that the platinum catalyst can accelerate the decomposition of ethanol.