Requirements for industrial work conditions are determined by human occupancy, building construction and production processes and they should ensure the prevention and removal of heat and noxious substances from the working space. Till now costly and time-consuming experimental methods in existing buildings and fast but less reliable simulation methods at the design stage were used, which both treat the human factor as minor. In the present study we propose a user-centered methodology which combined the versatility of the thermo-physiological modeling and the reliability of in-situ measurements based on an example of a typical industrial hall. Based on the results we observed insufficient operative temperature for winter and summer months due to the missing HVAC system in the hall. As a consequence, sweat excretion, thermal sensation and skin wettedness exceeded their limits for physiological strain and thermal comfort during the summer months, and skin temperature decreased distinctly at the face and hands but was still above the limit for pain or non-freezing cold injury in the winter months. This methodology can be used for a wide range of thermal environments, activities and clothing. It eliminates the need for the exposure of human beings and provides information on physiological data, which are difficult or impractical to measure in a field study (e.g. sweat excretion, skin and core temperatures, thermal sensation). The methodology can be useful to reveal zones with distractive effect or are inappropriate for human exposition. Finally, this approach also allows using a single method and providing continuous output information for a variety of environments without needing to change approach and type of output data. (C) 2018 Elsevier B.V. All rights reserved.