화학공학소재연구정보센터
Chemistry Letters, Vol.47, No.8, 1048-1050, 2018
Copper-catalyzed Cross-coupling Reaction between Aryl(trialkyl)silanes and Alkyl Halides
We report that simple aryl(trialkyl) silanes undergo crosscoupling reaction with alkyl (pseudo) halides in the presence of copper iodide/phenanthroline catalyst and cesium fluoride. Various aryl(trialkyl) silanes and alkyl electrophiles having iodine, bromine, chlorine, and tosyloxy group are applicable to the present reaction. Because such silanes are stable and readily accessible by catalytic C-H silylation, this protocol allows us to synthesize alkylarenes rapidly.