This study examines the potential contribution to biogas national production, by cultivating sunflower, using modern techniques, in the plains of the prefecture of Karditsa, Greece. The main purpose of this study is to determine the potential quantity of biogas that could be eventually produced in the plains, by applying the latest methods to the cultivation, growth and harvesting of the sunflower. Using regional and national data, this study ranked the agricultural areas of the prefecture of Karditsa and created a suitability map on the needs of the sunflower. The illustrated results provide some support for the future investors or the present farmers in the area. The developed GIS maps may become a useful tool for the prediction of the income from the calculated quantity and quality of sunflower crops' seeds or biogas production. Spatial planning analysis for the determination of the installation of a biogas' facility centre, where sunflower's derivatives will be processed for ethanol production was also implemented. On the basis of the results of this research, it can be concluded that Karditsa's plains have a great potential for producing 3818 ktoe of biogas and succeed Greece's 2020s goal on biofuel production (10% of total fuel consumption) by utilizing the maps and the techniques presented on this study. A supplementary study of converting waste (household bio-waste) to bioethanol and the future potentials of the process were illustrated and presented, based on the fact that bio-waste production is and will continue to increase. (C) 2018 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.